Related Experiment Video

Updated: Sep 5, 2025

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

644

Therapeutic effect of antihypertensive drug on diabetic nephropathy: Functional and structural kidney investigation

Seyedeh Masoumeh Ghoreishi1, Mehrangiz Amiri2, Ali Shabestani Monfared3

  • 1Cellular and Molecular Research Center, Babol University of Medical Sciences, Babol, Iran.

Saudi Journal of Biological Sciences
|July 8, 2022
PubMed

Insights

Carvedilol effectively treats diabetic nephropathy by improving kidney function and structure. This study demonstrates carvedilol

Area of Science:

  • Nephrology
  • Endocrinology
  • Pharmacology

Background:

  • Diabetic nephropathy is a major complication of diabetes mellitus (DM), necessitating effective treatments with minimal side effects.
  • Existing treatments for diabetic nephropathy often have limitations, driving the search for novel therapeutic agents.

Purpose of the Study:

  • To evaluate the therapeutic effects of carvedilol on both the functional and structural aspects of the kidney in a rat model of diabetic nephropathy.
  • To investigate carvedilol's impact on key biochemical markers and renal imaging in diabetic nephropathy.

Main Methods:

  • Diabetic nephropathy was induced in rats using streptozotocin (STZ).
  • Three groups were studied: control, diabetic, and diabetic treated with carvedilol.
  • Evaluated biochemical parameters (glucose, BUN, creatinine, uric acid, Na+, K+), histopathology, and SPECT imaging with 99mTc-DMSA.

Main Results:

  • Carvedilol treatment significantly reduced blood glucose, BUN, creatinine, uric acid, and potassium levels in diabetic rats.
  • Sodium levels increased towards normal ranges in the carvedilol-treated group.
  • Histopathological examination and SPECT imaging revealed significant improvements in renal structure and function in the carvedilol-treated group.

Conclusions:

  • Carvedilol demonstrates significant therapeutic effects in treating diabetic nephropathy, improving both kidney function and structure.
  • The findings support carvedilol as a potential treatment option for patients suffering from diabetic nephropathy.

Keywords:
Biochemical factorsCarvedilolDiabetesSPECT imaging

More Related Videos

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

278
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.4K

Related Concept Videos

Antihypertensive Drugs: Action of Diuretics01:16

Antihypertensive Drugs: Action of Diuretics

Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
862
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
477
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
503
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
56
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
734
Antihypertensive Drugs: Thiazide-Class Diuretics01:15

Antihypertensive Drugs: Thiazide-Class Diuretics

Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...
849