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Updated: Sep 5, 2025

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
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Is Ivermectin Effective in Treating COVID-19?

Shuangshuang Yang1,2, Shan Shen1, Ning Hou1

  • 1Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Frontiers in Pharmacology
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PubMed
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Ivermectin may help reduce mortality and hospitalization for COVID-19 patients. However, clear guidelines are lacking, and self-medication with ivermectin is not advised.

Keywords:
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Area of Science:

  • Infectious Diseases
  • Pharmacology

Background:

  • The COVID-19 pandemic necessitates urgent identification of effective treatments.
  • Ivermectin, an antiparasitic drug with known antiviral properties, has emerged as a potential therapeutic agent.

Approach:

  • A systematic review of studies published between December 2019 and March 2022 was conducted.
  • Searches were performed using major scientific databases: PubMed, Web of Science, and EBSCOhost.

Key Points:

  • Seven studies indicated lower mortality rates in patients treated with ivermectin compared to control groups.
  • Six studies reported significantly shorter hospital stays for the ivermectin group.
  • Eight studies demonstrated improved negative RT-PCR test results in patients receiving ivermectin.

Conclusions:

  • Ivermectin shows potential efficacy in treating patients with mild to moderate COVID-19.
  • Current evidence does not support definitive recommendations for ivermectin in COVID-19 treatment.
  • Physicians should exercise caution when considering ivermectin, and self-medication is strongly discouraged.