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Human papillomavirus bowel colonization in inflammatory bowel disease: A comparative case control study
Mahmoud H Mosli1, Marwan Albeshri1, Mohammad N Alsanea1
1Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Journal of Family Medicine and Primary Care
|July 8, 2022
Summary
Human papillomavirus (HPV) ileocolonic colonization was not detected in patients with inflammatory bowel disease (IBD). This study found no association between HPV and IBD diagnosis or disease severity, suggesting HPV is not an environmental trigger for IBD.
Area of Science:
- Gastroenterology
- Virology
- Epidemiology
Background:
- Environmental factors are investigated as triggers for inflammatory bowel disease (IBD).
- The role of human papillomavirus (HPV) in IBD pathogenesis remains unexplored.
- Bacterial pathogens have been the primary focus of IBD environmental trigger research.
Purpose of the Study:
- To investigate the association between HPV ileocolonic colonization and IBD.
- To determine if HPV colonization is linked to IBD diagnosis.
- To assess the relationship between HPV colonization and IBD disease severity.
Main Methods:
- A cross-sectional study design was employed.
- Mucosal biopsies were collected from IBD patients and controls during endoscopic evaluation.
- A hybrid capture assay was utilized to detect tissue HPV, with Fisher's exact test for comparisons.
Main Results:
- HPV colonization was detected in 4.1% of controls but in none of the IBD cases (P=0.05).
- A total of 201 patients were included: 104 with IBD and 97 controls.
- No HPV ileocolonic colonization was observed in IBD patients, irrespective of disease activity.
Conclusions:
- There is no evidence of HPV ileocolonic colonization in patients with IBD.
- HPV colonization does not appear to be associated with IBD diagnosis.
- HPV is unlikely to be an environmental trigger for inflammatory bowel disease.
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