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Angioimmunoblastic T-Cell Lymphoma: A Case Report.

Brittany Miles^1,2, Eseosa A Bazuaye-Ekwuyasi³, Jayati Mallick⁴

¹Medical Education, University of Texas Medical Branch, Galveston, USA.

|July 8, 2022

Summary

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive lymphoma. This case highlights rapid disease progression and worsening Epstein-Barr virus (EBV) positivity after initial treatment.

Keywords:

angioimmunoblastic t cell lymphoma epstein-barr virus positive diffuse large b-cell lymphoma extranodal involvement ipi (international prognostic index)stem cell transplant for hematological malignancies

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Area of Science:

Hematology
Oncology
Immunology

Background:

Angioimmunoblastic T-cell lymphoma (AITL) is a rare peripheral T-cell lymphoma.
AITL is characterized by an aggressive clinical course and poor treatment response.
No standard of care exists for AITL treatment.

Observation:

A patient with AITL presented with extranodal disease, including an FDG-avid subcutaneous nodule and probable spleen involvement.
The patient received initial treatment for AITL.
After two months, lymphoma grade escalated with worsening Epstein-Barr virus (EBV) positivity.

Findings:

Extranodal involvement in AITL impacts prognosis and International Prognostic Index (IPI) risk.
FDG-avid subcutaneous nodules can indicate extranodal AITL.
Rapid disease progression and EBV positivity worsening were observed post-treatment.

Implications:

Early identification of extranodal AITL is crucial for risk stratification.
Aggressive monitoring is needed for AITL patients, especially those with extranodal disease.
Further research into AITL pathogenesis and treatment is warranted, particularly concerning EBV association.