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Updated: Sep 5, 2025

Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
Lithium toxicity following Roux-en-Y gastric bypass: Mini review and illustrative case
Shahana Ayub1, Sundas Saboor2, Sadia Usmani1,2,3,4,5
1Psychiatrist, Cornerstone Family Health, Newburgh, New York.
Abstract:
Lithium is among the mainstays of treatment for bipolar disorder. Bariatric surgery can considerably change the oral bioavailability of drugs, particularly lithium. In this review, a 36-year-old male patient is described, who presented with lithium toxicity, including neurologic and gastric symptoms after undergoing Roux-en-Y gastric bypass. The mechanism of lithium toxicity is discussed; recommendations for clinicians regarding lithium use in postsurgical patients are provided; and previous case reports of lithium toxicity post-gastric bypass surgery are analyzed. Awareness and education of lithium absorption changes postbariatric surgery is essential for optimal patient care. Close clinical and drug concentration level monitoring is warranted.
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