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Coronary artery lesion distribution in patients with chronic kidney disease undergoing percutaneous coronary

Naofumi Ikeda1, Toshihide Hayashi2, Shikou Gen1

  • 1Department of Nephrology, Saitama Sekishinkai Hospital, Sayama, Japan.

Renal Failure
|July 8, 2022
PubMed

Insights

The prevalence of right coronary artery (RCA) lesions in patients with chronic kidney disease (CKD) increases with CKD stage. This suggests renal function impacts RCA atherosclerosis progression more than other coronary arteries.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology

Background:

  • Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease.
  • The distribution of coronary atherosclerosis in CKD patients requires further investigation.

Purpose of the Study:

  • To determine the distribution of coronary atherosclerosis in patients with varying stages of chronic kidney disease (CKD).
  • To clarify the association between renal function and the location/distribution of coronary atherosclerosis lesions.

Main Methods:

  • A cross-sectional study analyzed data from 1772 patients who underwent percutaneous coronary intervention after propensity score matching.
  • Renal function and angiographic characteristics of coronary atherosclerosis were examined.

Main Results:

  • Coronary lesions were most common in the left anterior descending coronary artery (LAD) (56%).
  • The prevalence of right coronary artery (RCA) lesions significantly increased with advancing CKD stages (26% in stage 1 to 59% in stage 5).
  • Logistic regression showed a 3.658 odds ratio for RCA lesions in CKD stage 5 compared to CKD stage 1.

Conclusions:

  • The prevalence of RCA lesions, unlike LAD or left circumflex coronary artery (LCX) lesions, escalates with increasing CKD stage.
  • Deterioration of renal function may disproportionately accelerate atherosclerosis progression in the RCA compared to LAD or LCX.
Abstract

Keywords:
Coronary atherosclerosisdistributionlocationmechanical force

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