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Vaping Cannabinoid Acetates Leads to Ketene Formation.

Kaelas R Munger1, Robert P Jensen2, Robert M Strongin1

  • 1Department of Chemistry, Portland State University, Portland, Oregon 97207, United States.

Chemical Research in Toxicology
|July 8, 2022
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Summary
This summary is machine-generated.

Vaping cannabinoid acetates, including delta-8 THC acetate, can produce the toxic gas ketene. This chemical was detected in vaping tests of multiple cannabinoid acetate products.

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Area of Science:

  • Cannabinoid chemistry
  • Vaping aerosol analysis
  • Toxicology

Background:

  • Delta-8 THC acetate is a novel psychoactive product available online and in vape shops.
  • Its structural similarity to vitamin E acetate, a known ketene precursor, raises safety concerns.

Purpose of the Study:

  • To investigate the potential for ketene formation from vaping delta-8 THC acetate.
  • To examine ketene formation from other cannabinoid acetates, specifically CBN acetate and CBD acetate.

Main Methods:

  • Vaping conditions were used to analyze cannabinoid acetates.
  • Vaped condensates were analyzed for the presence of ketene.

Main Results:

  • Ketene was consistently detected in vaped condensates from delta-8 THC acetate, CBN acetate, and CBD acetate.
  • Ketene was also observed in a commercial delta-8 THC acetate product.

Conclusions:

  • Vaping cannabinoid acetates, including delta-8 THC acetate, can generate toxic ketene.
  • Further research is needed to assess the health risks associated with inhaling ketene from vaped cannabinoid products.