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Updated: Sep 5, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Noncovalent Synergy: Aurophilicity and Aryl Stacking in Bis(gold(I)aryl)-dmpm Complexes
Felix Müller1, Martin Ertl2, Beate Neumann1
1Lehrstuhl für Anorganische Chemie und Strukturchemie; Centrum für Molekulare Materialien CM2, Fakultät für Chemie, Universität Bielefeld, Universitätsstraße 25, Bielefeld D-33615, Germany.
Abstract:
Bis(dimethylphosphino)methane (dmpm) was used as a ligand to synthesize four semi-supported dinuclear gold(I) complexes, dmpm(AuR)2 (R = Cl, C6H5, C6Cl5, and C6F5), which were studied concerning the synergistic effects of two weak noncovalent interactions: aurophilic and aryl-aryl stacking interactions. The chloro-substituted complex was synthesized by the ligand substitution of (tht)AuCl with dmpm and further functionalized by the reaction with PhMgBr or in situ-generated C6Cl5Li to afford the phenyl- and pentachlorophenyl-substituted compounds, respectively. The pentafluorophenyl-substituted gold complex was generated by the ligand substitution of (tht)Au(C6F5) with dmpm. All complexes were characterized by multinuclear NMR spectroscopy, CHN analyses, and X-ray diffraction experiments. Additionally, the basic photoluminescence properties of dmpm(AuCl)2, dmpm(AuC6Cl5)2, and dmpm(AuC6F5)2 were examined. The aggregation behavior of dmpm(AuC6F5)2 was further investigated by variable-temperature diffusion-ordered NMR spectroscopy experiments.
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