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Updated: Sep 5, 2025

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits

Jessica W Tsai1,2,3, Paloma Cejas4,5, Dayle K Wang1,3

  • 1Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

Cancer Research
|July 8, 2022
PubMed
Summary

Forkhead box R2 (FOXR2) is a potent oncogene epigenetically activated in most human cancers. This study reveals FOXR2 drives tumor growth by hijacking ETS transcription circuits, offering new therapeutic targets.

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