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Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses

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Published on: March 8, 2024

Hemolytic anemia in COVID-19.

Hayder M Al-Kuraishy¹, Ali I Al-Gareeb¹, Ajeet Kaushik²

¹Department of Clinical Pharmacology and Medicine, College of Medicine, ALmustansiriyia University, M.B.Ch.B, FRCP, Baghdad, Iraq.

Annals of Hematology

|July 8, 2022

Summary

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) can cause hemolytic anemia through direct cell injury or autoimmune responses. Early detection and monitoring are crucial for managing this COVID-19 complication.

Keywords:

Autoimmune hemolytic anemia COVID-19 SARS-CoV-2

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Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

Area of Science:

Hematology
Virology
Immunology

Background:

COVID-19, caused by SARS-CoV-2, is a global pandemic.
SARS-CoV-2 interacts with host cells via ACE2, CD147, and erythrocyte Band3 protein.
Hemolytic anemia is a recognized complication of COVID-19.

Purpose of the Study:

To comprehensively review the mechanisms linking SARS-CoV-2 infection to hemolytic anemia.
To highlight the direct and indirect pathways of erythrocyte injury.
To emphasize the importance of early diagnosis and management.

Main Methods:

Literature review of studies on SARS-CoV-2, hemolytic anemia, and related mechanisms.
Analysis of potential direct cytopathic effects of the virus on erythrocytes.
Examination of indirect mechanisms, including autoantibody induction.

Main Results:

SARS-CoV-2 can induce hemolytic anemia directly via cytopathic injury to erythrocytes.
Indirectly, SARS-CoV-2 infection can trigger autoimmune hemolytic anemia through autoantibody formation.
Hemolytic exacerbations may also occur due to COVID-19 treatments and vaccination.

Conclusions:

SARS-CoV-2 infection presents a dual risk for hemolytic anemia, through direct injury and autoimmune pathways.
Early detection and management of SARS-CoV-2-induced hemolytic anemia are vital for improving COVID-19 patient outcomes.
Ongoing monitoring for hemolytic complications is necessary, considering potential drug and vaccine-related exacerbations. Intelligent nanosystems show promise for early diagnosis.