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Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
Published on: November 4, 2015
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Stroke and embolism in patients with left ventricular hypertrabeculation/noncompaction
Katja Schiebel1, Josef Finsterer1, Patrick Lazarevic2
1Klinik Landstraße, Juchgasse 25, Steingasse 31/18, Wien A-1030, Österreich.
Summary
Left ventricular hypertrabeculation/noncompaction (LVHT) patients with stroke or embolism (S/E) have more cardiovascular risk factors. LVHT alone is a minor risk factor for S/E, necessitating etiological investigations.
Area of Science:
- Cardiology
- Neurology
- Genetics
Background:
- Left ventricular hypertrabeculation/noncompaction (LVHT) is a rare congenital heart condition characterized by excessive trabeculations in the left ventricle.
- LVHT has been anecdotally associated with an increased risk of stroke or embolism (S/E).
Purpose of the Study:
- To compare the characteristics and prognosis of LVHT patients with and without S/E.
- To identify potential risk factors for S/E in LVHT patients.
Main Methods:
- Retrospective analysis of consecutive LVHT patients diagnosed between 1995 and 2020.
- Collection of baseline characteristics and follow-up data.
- Etiology of S/E assessed using Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria.
Main Results:
- Out of 319 LVHT patients, 49 (15%) experienced S/E (44 stroke, 3 peripheral embolism, 2 both).
- Patients with S/E were older and had higher rates of arterial hypertension, diabetes mellitus, atrial fibrillation, neuromuscular disorders, and heart transplantation.
- Cardioembolic causes accounted for the majority of S/E (n=32), but other etiologies were also identified.
Conclusions:
- Cardiovascular risk factors are more prevalent in LVHT patients who experience S/E.
- S/E in LVHT patients is not exclusively cardioembolic, underscoring the importance of etiological investigations.
- LVHT itself appears to be a minor risk factor for S/E.
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