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Taming the transposon: H3K9me3 turns foe to friend in human development
Alisha Chitrakar1, Mackenzie Noon1, Andrew Zhuo Xiao1
1Department of Genetics and Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA.
Abstract:
In this issue of Cell Stem Cell, Xu et al. and Yu et al. use low-input epigenetic profiling techniques to map H3K9me3 deposition in early human development. They reveal stage-specific H3K9me3 deposition on retrotransposons, which may play crucial cis-regulatory roles in early development.
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