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Structures of EBI2 shed light on the treatment of autoimmune diseases

Jinkang Shen1, Haitao Zhang2

  • 1Hangzhou Institute of Innovative Medicine, Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.

Structure (London, England : 1993)
|July 8, 2022
PubMed

Insights

The oxysterol receptor EBI2 controls immune cell movement and antibody production. New cryo-EM structures reveal how EBI2 binds ligands and signals, offering insights into immune regulation.

Area of Science:

  • Structural Biology
  • Immunology
  • Molecular Biology

Background:

  • The oxysterol receptor EBI2 (Epstein-Barr virus-induced gene 2) plays a critical role in regulating immune responses.
  • EBI2 mediates the migration of B and T cells, crucial for adaptive immunity.
  • It also influences antibody production, impacting humoral immunity.

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