Association of Stroke Lesion Pattern and White Matter Hyperintensity Burden With Stroke Severity and Outcome

Anna K Bonkhoff¹, Sungmin Hong², Martin Bretzner²+54

• ¹From the J. Philip Kistler Stroke Research Center (A.K.B., S.H., M.B., M.D.S., R.W.R., E.M.A., K.D., M.N., M.R.E., J. Rosand, N.S.R.), Massachusetts General Hospital, Harvard Medical School, Boston; Univ. Lille (M.B.), Inserm, CHU Lille, U1171-LilNCog (JPARC)-Lille Neurosciences & Cognition, France; Clinic for Neuroradiology (M.D.S.), University Hospital Bonn, Germany; Computer Science and Artificial Intelligence Lab (A. Dalca, P.G.), Massachusetts Institute of Technology, Boston; Athinoula A. Martinos Center for Biomedical Imaging (A. Dalca, B.L.H., S.J.T.M., E.M., J. Rosand, O.W.), Department of Radiology, Massachusetts General Hospital, Charlestown; Department of Neurology (A.-K.G.), University Medical Center Hamburg-Eppendorf, Germany; Hunter Medical Research Institute (J.A.), Newcastle; School of Medicine and Public Health, University of Newcastle, New South Wales, Australia; Department of Medicine (O.B.), Division of Neurology, University of British Columbia, Vancouver, Canada; Department of Neurology (J.W.C., S.K.), University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System, Baltimore; School of Medical Sciences (A. Donatti, A. Sousa), University of Campinas (UNICAMP) and the Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), Campinas, SP, Brazil; Department of Neurosurgery (C.G.), Geisinger, Danville, PA; Department of Neurosurgery (C.G.), Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria; Department of Emergency Medicine (L. Heitsch), Washington University School of Medicine; Department of Neurology (L. Heitsch, C.-L.P.), Washington University School of Medicine & Barnes-Jewish Hospital, St. Louis, MO; Department of Clinical Neuroscience (L. Holmegaard, K.J., T.T.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg; Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Neurology (J.J.-C., J. Roquer), Neurovascular Research Group (NEUVAS), IMIM-Hospital del Mar (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autonoma de Barcelona, Spain; KU Leuven-University of Leuven (R.L.), Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND); VIB, Vesalius Research Center, Laboratory of Neurobiology, University Hospitals Leuven, Department of Neurology, Belgium; School of Medicine and Public Health (C.L.), University of Newcastle; Department of Neurology, John Hunter Hospital, Newcastle, New South Wales, Australia; Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (C.W.M.), University of Florida, Gainesville; Department of Neurology (J. Meschia), Mayo Clinic, Jacksonville, FL; Centogene AG (A.R.), Rostock, Germany; Department of Neurology (S.R., R.S.), Clinical Division of Neurogeriatrics, Medical University Graz, Austria; Henry and Allison McCance Center for Brain Health (J. Rosand), Massachusetts General Hospital, Boston; Department of Neurology and Evelyn F. McKnight Brain Institute (T.R., R.L.S.), Miller School of Medicine, University of Miami, FL; Institute of Cardiovascular Research (P.S.), Royal Holloway University of London (ICR2UL), Egham, UK St Peter's and Ashford Hospitals, United Kingdom; Department of Neurology (A. Slowik), Jagiellonian University Medical College, Krakow, Poland; Department of Clinical Sciences Malmö (M.S.), Lund University; Department of Neurology, Skåne University Hospital, Lund and Malmö; Department of Laboratory Medicine (T.M.S., C.J.), Institute of Biomedicine, the Sahlgrenska Academy, University of Gothenburg, Sweden; Department of Neurology (D.S.), Helsinki University Hospital and University of Helsinki, Finland; Stroke Division (V.T.), Florey Institute of Neuroscience and Mental Health and Department of Neurology, Austin Health, Heidelberg, Australia; Department of Radiology (A.V.), University of Cincinnati College of Medicine, OH; Department of Clinical Sciences Lund (J.W.), Radiology, Lund University; Department of Radiology, Neuroradiology, Skåne University Hospital, Lund, Sweden; Department of Neurology and Rehabilitation Medicine (D.W.), University of Cincinnati College of Medicine, OH; Department of Neurology (R.Z.), Geisinger, Danville, PA; Division of Endocrinology (P.M.), Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore; Departments of Neurology and Public Health Sciences (B.B.W.), University of Virginia, Charlottesville; Department of Clinical Genetics and Genomics (C.J.), Sahlgrenska University Hospital, Gothenburg; Department of Neurology (A.G.L.), Skåne University Hospital, Lund; Department of Clinical Sciences Lund, Neurology, Lund University, Sweden; University of Technology Sydney (J. Maguire), Australia; Department of Biomedical Engineering (D.B.), McConnell Brain Imaging Centre, Montreal Neurological Institute, Faculty of Medicine, School of Computer Science, McGill University; and Mila-Quebec Artificial Intelligence Institute (D.B.), Montreal, Canada. abonkhoff@mgh.harvard.edu.+1