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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
Published on: June 7, 2018
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Liquid-liquid phase separation in tumor biology
Xuhui Tong1,2, Rong Tang3,4, Jin Xu1,2
1Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Signal Transduction and Targeted Therapy
|July 8, 2022
Summary
Liquid-liquid phase separation (LLPS) drives cellular organization and function. Aberrant LLPS contributes to cancer, offering new therapeutic targets for tumor treatment.
Area of Science:
- Cell Biology
- Biophysics
- Cancer Biology
Background:
- Liquid-liquid phase separation (LLPS) is a fundamental mechanism for cellular organization.
- LLPS forms biomolecular condensates, regulating key cellular processes like DNA repair and transcription.
- Dysregulation of these processes is implicated in cancer development.
Purpose of the Study:
- To review the mechanisms of biomolecular condensate formation and function.
- To summarize LLPS's role in cancer cell pathology.
- To discuss therapeutic strategies targeting LLPS in cancer.
Main Methods:
- Comprehensive literature review of LLPS in cell biology and cancer.
- Analysis of biophysical principles governing condensate formation.
- Examination of emerging therapeutic approaches targeting aberrant LLPS.
Main Results:
- LLPS is crucial for spatiotemporal regulation within cells.
- Aberrant LLPS is linked to malignant transformations and cancer progression.
- Targeting LLPS presents promising avenues for cancer therapy.
Conclusions:
- Biomolecular condensates formed by LLPS are critical for cellular functions.
- Abnormal LLPS contributes significantly to cancer pathology.
- Modulating LLPS holds therapeutic potential for combating tumorigenesis.
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