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Interstitial potentials and their change with depth into cardiac tissue.

R Plonsey, R C Barr

    Biophysical Journal
    |April 1, 1987
    PubMed
    Summary

    Interstitial potential fields significantly impact electrical source strength in cardiac muscle. These potentials can be ignored only in very thin tissues (under 200 microns).

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    Area of Science:

    • Biophysics
    • Cardiac Electrophysiology
    • Computational Biology

    Background:

    • The transmembrane current approximates electrical source strength in isolated excitable fibers.
    • In multicellular cardiac preparations, interstitial potential fields can alter electrical source strength.

    Purpose of the Study:

    • To investigate the magnitude of the interstitial potential field within cardiac muscle.
    • To determine the influence of tissue depth on interstitial potentials.

    Main Methods:

    • Modeling cardiac ventricular muscle as a syncytium and a continuum using the bidomain model.
    • Assuming a uniform propagating plane wave of excitation.
    • Analyzing the interstitial potential field as a function of depth.

    Main Results:

    • The calculated interstitial potential field is inconsistent with typical volume conductor models.
    • Interstitial potentials are significant and do not diminish rapidly with depth.
    • The influence of interstitial potentials is negligible only in tissues thinner than 200 microns.

    Conclusions:

    • Interstitial potentials play a crucial role in determining electrical source strength in cardiac muscle.
    • The continuum (bidomain) model provides a more accurate representation of electrical fields in cardiac tissue.
    • Current approximations for volume conductors may be inadequate for thicker cardiac tissue preparations.

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