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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Prostate Cancer Survivors Present Long-Term, Residual Systemic Immune Alterations.

Katalin Balázs1,2, Zsuzsa S Kocsis3, Péter Ágoston4,5

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Prostate cancer survivors may experience lasting immune system changes after treatment. While NK cell function recovered, adaptive immune alterations persisted long-term.

Keywords:
adaptive immune responseimmune phenotypinginnate immune responseprostate cancerradiotherapy

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Area of Science:

  • Immunology
  • Oncology
  • Cancer Therapy

Background:

  • Cancer and its treatments can cause immune system changes.
  • Long-term immune dysfunction in cancer survivors is not well understood.

Purpose of the Study:

  • To investigate persistent immune alterations in prostate cancer survivors.
  • To track cellular immune parameters up to 3 years post-brachytherapy.

Main Methods:

  • Followed cellular immune parameters in prostate cancer patients.
  • Utilized low dose rate brachytherapy for treatment.
  • Monitored patients for 36 months post-therapy.

Main Results:

  • Reduced CD4+ T cells and increased regulatory T cells persisted.
  • Natural Killer (NK) cell numbers and function recovered after tumor regression.
  • Lymphoid Dendritic Cells (DCs) fraction increased, and some protein levels normalized.

Conclusions:

  • NK cell dysfunction recovered, but adaptive immune system alterations remained.
  • Partial long-term immune dysfunction was observed in cancer survivors.