Risk Factors and Clinicopathological Features for Developing a Subsequent Primary Cutaneous Squamous and Basal Cell...

Area of Science:

• Dermatology
• Oncology
• Epidemiology

Background:

• Patients diagnosed with keratinocyte carcinomas (KCs) exhibit a higher risk for developing subsequent skin cancers.
• Existing research emphasizes regular follow-up for patients with KCs but lacks detail on subtype-specific risks for further KC development.
• This study investigates the relationship between specific KC subtypes and the risk of subsequent skin cancer development.

Purpose of the Study:

• To assess the varying risks of subsequent skin cancer development following a primary KC diagnosis, considering specific KC subtypes.
• To identify key factors associated with an increased risk of new cutaneous tumors.
• To explore non-invasive diagnostic and monitoring strategies for KCs.

Main Methods:

• A retrospective analysis of pathology and medical records was conducted.
• Data from 10,083 patients diagnosed with 13,913 KCs between 1999 and 2019 were examined.
• Patient characteristics were analyzed to identify risk factors for multiple KCs.

Main Results:

• A total of 13,913 KCs were identified in 10,083 patients, with 22.8% (2300 patients) developing multiple KCs.
• Aggressive KC subtypes, a history of multiple tumors, and male sex were identified as significant prognostic factors.
• Specific basal cell carcinoma subtypes, like infiltrative basosquamous carcinoma, demonstrated aggressive growth patterns.

Conclusions:

• Male gender, aggressive tumor subtypes, and a history of multiple skin cancers are the primary risk factors for developing subsequent KCs.
• Aggressive KC subtypes, particularly infiltrative basosquamous carcinoma, are associated with an increased risk of recurrence and subsequent KCs.
• Understanding these risk factors can guide personalized monitoring and management strategies for patients with a history of KC.