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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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p53 Isoforms as Cancer Biomarkers and Therapeutic Targets

Liuqun Zhao1, Suparna Sanyal1

  • 1Department of Cell and Molecular Biology, Uppsala University, SE-75124 Uppsala, Sweden.

Cancers
|July 9, 2022
PubMed

Insights

This review explores how p53 isoforms, such as Δ40p53, Δ133p53, and Δ160p53, impact aggressive cancer development and suggests therapeutic strategies targeting these variants for improved diagnosis and treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genetics

Background:

  • The tumor suppressor protein p53 plays a critical role in preventing cancer.
  • Aberrant expression and function of p53 isoforms are increasingly implicated in aggressive cancer.
  • Understanding the complex network of p53 isoforms is crucial for cancer research.

Purpose of the Study:

  • To review the implications of major p53 isoforms in aggressive cancer development.
  • To elucidate the involvement of p53 isoforms in cell-signaling pathways and protein interactions.
  • To explore the clinical relevance of p53 isoforms in cancer diagnosis and therapy.

Main Methods:

  • Comprehensive literature review of existing studies on p53 isoforms.
  • Analysis of p53 isoform involvement in various cancer types.
  • Synthesis of current knowledge on p53 isoform function and regulation.

Main Results:

  • Major p53 isoforms (Δ40p53, Δ133p53, Δ160p53) exhibit complex roles in cancer.
  • These isoforms are involved in intricate molecular networks regulating oncogenic functions.
  • Alterations in cellular levels of p53 isoforms are linked to cancer progression.

Conclusions:

  • p53 isoforms have significant clinical relevance in cancer diagnosis.
  • Targeting specific p53 isoforms offers potential therapeutic strategies for cancer treatment.
  • Further research into p53 isoform networks may unlock novel cancer therapies.
Keywords:
biomarkercancerp53 isoformstherapeutic target

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