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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Related Experiment Video

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Cell Population Analyses During Skin Carcinogenesis
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Multiple Basal Cell Carcinomas in Immunocompetent Patients.

Paola Savoia1, Federica Veronese2, Lara Camillo1

  • 1Department of Health Sciences, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy.

Cancers
|July 9, 2022
PubMed
Summary

Multiple basal cell carcinomas (BCCs) are common, even in immunocompetent individuals. Male gender, older age, and nodular BCC type are key risk factors, necessitating surveillance programs for early detection.

Keywords:
UV-exposurebasal cell carcinomahedgehog pathwaymutational statusnon-melanoma skin cancerrisk factors

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Area of Science:

  • Dermatology
  • Oncology
  • Genetics

Background:

  • Multiple basal cell carcinomas (BCCs) are prevalent in both immunosuppressed and general populations.
  • Specific risk factors for BCC development in immunocompetent individuals remain unclear.
  • Somatic mutations in the hedgehog pathway are implicated in BCC pathogenesis.

Purpose of the Study:

  • To identify risk factors associated with the development of multiple BCCs in a cohort of surgically treated patients.
  • To evaluate clinical and histopathological characteristics of patients with multiple BCCs.

Main Methods:

  • Retrospective observational study of patients diagnosed and surgically treated for BCCs over five years.
  • Analysis of clinical data, histopathological findings, and potential risk factors.

Main Results:

  • 506 patients (24.2%) had multiple BCCs (1516 total lesions).
  • Multiple BCCs were more common in males, older individuals, and often presented on the trunk with a nodular histotype.
  • Male gender, older age, nodular BCC, and facial involvement at initial diagnosis were identified as risk factors.

Conclusions:

  • The significant incidence of multiple BCCs in non-immunocompromised individuals highlights the need for vigilant surveillance.
  • Early diagnosis and treatment through regular monitoring programs are crucial for managing additional BCC occurrences.