Related Experiment Video
Updated: Sep 5, 2025
08:54
An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells
Published on: July 20, 2014
14.1K
Sex Differences in Neoplastic Progression in Barrett's Esophagus: A Multicenter Prospective Cohort Study
Carlijn A M Roumans1,2, Pauline A Zellenrath1, Ewout W Steyerberg2,3
1Department of Gastroenterology & Hepatology, Erasmus MC University Medical Center, 3015 GD Rotterdam, The Netherlands.
Cancers
|July 9, 2022
Summary
Men with Barrett's esophagus (BE) have a higher risk and faster progression to esophageal cancer. However, women are diagnosed with more advanced esophageal adenocarcinoma (EAC). Sex-specific risk models are needed for better Barrett's esophagus management.
Area of Science:
- Gastroenterology
- Oncology
- Epidemiology
Background:
- Barrett's esophagus (BE) management guidelines often lack sex-specific considerations.
- Existing data primarily reflects male patient populations, potentially overlooking sex-based differences in disease progression.
Purpose of the Study:
- To investigate sex-based disparities in neoplastic progression probability and timing within Barrett's esophagus.
- To analyze differences in neoplasia stage distribution between male and female BE patients.
Main Methods:
- A multicenter prospective cohort study involving 868 BE patients.
- Utilized Cox regression and accelerated failure time modeling to assess sex differences.
- Neoplastic progression defined as high-grade dysplasia (HGD) and/or esophageal adenocarcinoma (EAC).
Main Results:
- Males exhibited a twofold higher risk of neoplastic progression (HR 2.26) and a shorter time to HGD/EAC (AR 0.52) compared to females.
- The risk of HGD was significantly higher in males (HR 3.76).
- Females were proportionally more diagnosed with EAC, often at higher stages.
Conclusions:
- Male BE patients face a greater risk and faster progression to neoplasia.
- Females, while having a lower risk, are diagnosed with proportionally more advanced EAC.
- Incorporating sex disparities into risk stratification models is crucial for personalized BE management.
Related Concept Videos
01:21Barrett Esophagus-I: Introduction
191
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
191
01:21Barrett Esophagus-II: Clinical Manifestations and Management
286
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
286
02:07Tumor Progression
6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K
01:30Esophageal Strictures-I: Introduction
258
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
258
01:24Esophagus
1.3K
The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
1.3K
01:26Esophageal Strictures-II: Clinical Features and Management
155
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
155