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MAFLD and CKD: An Updated Narrative Review.
Alessandro Mantovani1, Rosa Lombardi2,3, Filippo Cattazzo4
1Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, Italy.
International Journal of Molecular Sciences
|July 9, 2022
Summary
Non-alcoholic fatty liver disease (NAFLD) and metabolic associated fatty liver disease (MAFLD) are linked to chronic kidney disease (CKD). Current evidence suggests MAFLD may identify patients with CKD as accurately as NAFLD.
Area of Science:
- Hepatology
- Nephrology
- Metabolic Diseases
Background:
- Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease globally.
- NAFLD is independently associated with an increased risk of incident chronic kidney disease (CKD).
- NAFLD is linked to metabolic dysfunction, including insulin resistance, obesity, and type 2 diabetes mellitus.
Purpose of the Study:
- To review epidemiological evidence on the association between NAFLD and CKD risk.
- To examine epidemiological data investigating the relationship between MAFLD and CKD risk.
- To discuss potential biological mechanisms linking NAFLD/MAFLD to CKD.
Main Methods:
- Narrative review of observational studies.
- Analysis of epidemiological data on NAFLD and CKD.
- Analysis of epidemiological data on MAFLD and CKD.
Main Results:
- NAFLD is associated with an increased risk of incident CKD.
- Preliminary evidence suggests MAFLD may identify patients with CKD as accurately as NAFLD.
- Further research is required to assess the concordance and potential superiority of MAFLD over NAFLD in detecting CKD risk.
Conclusions:
- Both NAFLD and MAFLD are associated with CKD.
- MAFLD may be a useful surrogate for NAFLD in identifying patients at risk of CKD.
- Understanding the shared mechanisms between fatty liver disease and CKD is crucial.
Keywords:
CKDMAFLDNAFLDNASHchronic kidney diseasemetabolic associated fatty liver diseasenon-alcoholic fatty liver diseasenon-alcoholic steatohepatitisMore Related Videos
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