Related Experiment Video
Updated: Sep 5, 2025
07:23
Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
Published on: December 3, 2016
12.0K
Special Issue "Bone Ontogeny, Embryology, and Homeostasis"
1Departments of Medical Education and Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, P.O. Box 70300, Johnson City, TN 37614, USA.
International Journal of Molecular Sciences
|July 9, 2022
Summary
This special issue explores bone development and homeostasis, focusing on molecular-level research in the skeletal system. Discover recent advancements in understanding bone biology from embryology to adulthood.
Area of Science:
- Bone biology and skeletal system research.
- Developmental biology and embryology.
- Molecular and cellular biology.
Background:
- This special issue focuses on the ontogeny, embryology, and homeostasis of bone.
- It highlights recent research advancements in skeletal biology.
- The content emphasizes a molecular-level understanding of the skeletal system.
Discussion:
- Exploring the intricate processes of bone formation and maintenance.
- Integrating molecular insights into the broader context of skeletal health.
- Discussing the implications of new research for understanding bone disorders.
Key Insights:
- Recent molecular research has significantly advanced our understanding of bone development.
- Homeostasis mechanisms in bone are complex and involve multiple molecular pathways.
- Embryonic development lays the foundation for adult skeletal structure and function.
Outlook:
- Future research directions in skeletal biology and molecular bone research.
- Potential therapeutic targets identified through molecular-level investigations.
- Advancing the understanding of skeletal diseases through continued molecular exploration.
Related Concept Videos
01:40Bone Remodeling
38.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.5K
01:29Bone Disorders
3.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.9K
01:17Hormones and Bone Tissue
2.9K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.9K
01:29Bone Formation by Intramembranous Ossification
7.2K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
7.2K
01:55Bone Structure
49.0K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
49.0K
01:21Skeleton and Calcium Homeostasis
4.7K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.7K