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Interleukin 15 in Cell-Based Cancer Immunotherapy

Yang Zhou1, Tiffany Husman1, Xinjian Cen1

  • 1Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095, USA.

International Journal of Molecular Sciences
|July 9, 2022
PubMed

Cell-based cancer immunotherapy, such as chimeric antigen receptor (CAR) engineered T and natural killer (NK) cell therapies, has become a revolutionary new pillar in cancer treatment. Interleukin 15 (IL-15), a potent immunostimulatory cytokine that potentiates T and NK cell immune responses, has demonstrated the reliability and potency to potentially improve the therapeutic efficacy of current cell therapy. Structurally similar to interleukin 2 (IL-2), IL-15 supports the persistence of CD8+ memory T cells while inhibiting IL-2-induced T cell death that better maintains long-term anti-tumor immunity. In this review, we describe the biology of IL-15, studies on administrating IL-15 and/or its derivatives as immunotherapeutic agents, and IL-15-armored immune cells in adoptive cell therapy. We also discuss the advantages and challenges of incorporating IL-15 in cell-based immunotherapy and provide directions for future investigation.

Keywords:
NK cellT celladoptive cell transfercancerchimeric antigen receptorengineeringimmunotherapyinterleukin 15

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