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Related Experiment Video

Updated: Sep 5, 2025

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
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Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing.

Zhiguo Liu1, Tianwen Wu1, Guangming Xiang1

  • 1State Key Laboratory of Animal Nutrition, Key Laboratory of Animal Genetics Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

International Journal of Molecular Sciences
|July 9, 2022
PubMed
Summary

CRISPR/Cas genome editing revolutionizes farm animal breeding, enabling rapid genetic enhancement for traits like disease resistance and production. Genome-edited animals (GEAs) offer future agricultural benefits despite current regulatory challenges.

Keywords:
disease resistancegenome editinglivestock animalsprecision breedingregulatory system

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Area of Science:

  • Agricultural Science
  • Genetics
  • Biotechnology

Background:

  • Animal breeding aims to improve economic traits through genetic enhancement.
  • The CRISPR/Cas system offers advanced genome editing capabilities for mammals.
  • Genetic engineering in agriculture has been transformed by these tools.

Purpose of the Study:

  • Review advancements in CRISPR/Cas genome editing tools.
  • Discuss applications in farm animal breeding.
  • Cover regulations and future prospects of genome-edited animals (GEAs).

Main Methods:

  • Literature review of CRISPR/Cas technology.
  • Analysis of applications in improving disease resistance, production, and welfare.
  • Examination of regulatory frameworks for GEAs.

Main Results:

  • CRISPR/Cas enables rapid genetic modification in farm animals within one generation.
  • Applications focus on enhancing disease resistance, production performance, and animal welfare.
  • The review covers regulatory aspects and strategies to accelerate GEA adoption.

Conclusions:

  • Genome editing breeding and GEAs hold significant promise for the future of agriculture.
  • Despite challenges, the technology is poised for near-future availability.
  • CRISPR/Cas tools fundamentally revolutionize farm animal genetic engineering.