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Related Experiment Video

Updated: Sep 5, 2025

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach
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Inclusion Body Myositis and Neoplasia: A Narrative Review.

Laura Damian1,2, Cristian Cezar Login3, Carolina Solomon4,5

  • 1Centre for Rare Autoimmune and Autoinflammatory Diseases (ERN-ReCONNET), Department of Rheumatology, Emergency Clinical County Hospital Cluj, 400347 Cluj-Napoca, Romania.

International Journal of Molecular Sciences
|July 9, 2022
PubMed
Summary

Inclusion body myositis (IBM) shares pathogenic mechanisms with cancer, including immune cell involvement and cellular pathway dysregulation. Further research is needed to understand this link and improve therapies for both conditions.

Keywords:
antibodies to the cytosolic 5′-nucleotidase 1A (anti-cN1A)autophagycancerinclusion body myositisinterferon γlarge granular lymphocytes leukemia (LGLL)lymphocyte exhaustionlymphocyte senescencemitochondriaparaneoplastic

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Area of Science:

  • Neurology
  • Immunology
  • Oncology

Background:

  • Inclusion body myositis (IBM) is an inflammatory myopathy often diagnosed late.
  • While other inflammatory myopathies are linked to malignancy, IBM is typically not considered paraneoplastic.
  • Existing studies often exclude IBM patients, potentially underestimating cancer associations.

Purpose of the Study:

  • To review pathogenic mechanisms in IBM.
  • To outline shared mechanisms between IBM and malignancy.
  • To explore therapeutic perspectives for IBM and associated cancers.

Main Methods:

  • Literature review of pathogenic mechanisms in IBM.
  • Analysis of shared subcellular and molecular pathways in IBM and cancer.
  • Examination of therapeutic strategies for IBM and malignancy.

Main Results:

  • CD8+ cytotoxic T cells with NK features are central to IBM pathogenesis.
  • Interferon gamma plays a key role, particularly in early IBM.
  • Shared pathways include mitochondrial dysfunction, autophagy, cell cycle, and metabolic crosstalk.

Conclusions:

  • Subcellular mechanisms in IBM and neoplasia are intermingled and likely underestimated.
  • The association between IBM and cancer warrants further investigation.
  • Understanding this link may lead to improved therapies, muscle function, and survival for IBM patients.