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PAX8 in the Junction between Development and Tumorigenesis.

Reli Rachel Kakun1,2, Zohar Melamed3, Ruth Perets1,2,3

  • 1Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3109601, Israel.

International Journal of Molecular Sciences
|July 9, 2022
PubMed
Summary

Embryonic development and cancer share common pathways and proteins. This review highlights PAX8, a key developmental transcription factor, and its pro-tumorigenic role in thyroid, kidney, and genital tract cancers.

Keywords:
PAX8embryogenesisendometrial cancerfallopian tubekidneyovarian cancerrenal cancerthyroidthyroid canceruterus

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Area of Science:

  • Developmental Biology
  • Oncology
  • Molecular Biology

Background:

  • Cancer development often reactivates embryonic developmental pathways.
  • Shared proteins between embryonic development and cancer cells drive this correlation.
  • Embryonic transcription factors, like PAX8, are crucial regulators of cell fate.

Purpose of the Study:

  • To review the role of PAX8 in embryonic development.
  • To examine PAX8's function in adult tissues.
  • To highlight PAX8's pro-tumorigenic role in specific cancers.

Main Methods:

  • Literature review of PAX8's function in development and cancer.
  • Analysis of PAX8's role in thyroid, kidney, and genital tract development.
  • Examination of PAX8's oncogenic potential in related malignancies.

Main Results:

  • PAX8 is a master transcriptional regulator in embryonic development of the thyroid, kidney, and genital tracts.
  • PAX8 plays roles in differentiation and cell fate determination.
  • PAX8 is implicated in the pro-tumorigenic progression of cancers in these organs.

Conclusions:

  • PAX8 is a critical developmental factor with significant implications in cancer.
  • Understanding PAX8's dual role in development and cancer is vital for therapeutic strategies.
  • PAX8's reactivation in cancer highlights the link between embryogenesis and tumorigenesis.