Related Experiment Video
Updated: Sep 5, 2025
08:09
Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics
Published on: June 17, 2012
19.8K
TritiKBdb: A Functional Annotation Resource for Deciphering the Complete Interaction Networks in Wheat-Karnal Bunt
Naveen Duhan1,2, Raghav Kataria1,2, Rakesh Kaundal1,2,3
1Department of Plants, Soils, and Climate, College of Agriculture and Applied Sciences, Utah State University, Logan, UT 84322, USA.
International Journal of Molecular Sciences
|July 9, 2022
Summary
Researchers developed TritiKBdb, a new database and webserver, to study plant-pathogen interactions. This resource aids in understanding wheat
Area of Science:
- Plant pathology and molecular biology
- Bioinformatics and computational biology
Background:
- Inter-species protein-protein interactions are vital for plant disease mechanisms and host immunity.
- Karnal bunt (Tilletia indica) significantly impacts wheat exports and causes economic losses.
- Limited information exists on T. indica interactions, hindering understanding of wheat-T. indica disease dynamics.
Purpose of the Study:
- To develop a comprehensive database and webserver, TritiKBdb, for studying protein-protein interactions in the Triticum species-Tilletia indica pathosystem.
- To provide tools for visualizing and comparing predicted interaction networks.
- To offer functional annotations for host and pathogen proteins.
Main Methods:
- Development of a novel database and webserver (TritiKBdb).
- Implementation of an 'interactomics' tool for network visualization and comparison.
- Integration of functional annotations including subcellular localization, domains, KEGG pathways, and GO terms.
Main Results:
- TritiKBdb provides a user-friendly platform for exploring host-pathogen protein interactions.
- The database includes information on transcription factors and effectors.
- Predicted interaction networks can be visualized and compared.
Conclusions:
- TritiKBdb serves as a valuable resource for researchers studying plant-pathogen interactions.
- The database facilitates a deeper understanding of Karnal bunt infection mechanisms in wheat.
- TritiKBdb is freely accessible for public use.
Related Concept Videos
02:26Protein Networks
4.1K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.1K
01:19Interactions Between Signaling Pathways
6.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.4K
02:54Canonical Wnt Signaling Pathway
8.9K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.9K
02:26Defenses Against Pathogens and Herbivores
25.4K
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
25.4K
01:25Cell Signaling in Plants
5.7K
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
5.7K
01:41Non-Canonical Wnt Signaling Pathways
7.4K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.4K