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Vitamin D Status, Cardiovascular Risk Profile, and miRNA-21 Levels in Hypertensive Patients: Results of the HYPODD

Domenico Rendina1, Lanfranco D Elia1, Veronica Abate1

  • 1Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.

Nutrients
|July 9, 2022
PubMed

Insights

Correcting vitamin D deficiency in hypertensive patients improved cardiovascular risk factors. However, vitamin D treatment did not alter circulating miR-21 levels in this population.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Molecular Biology

Background:

  • Vitamin D and microRNAs (miRs) are implicated in cardiometabolic disorders like hypertension.
  • Hypovitaminosis D is common and may contribute to cardiovascular disease progression.

Purpose of the Study:

  • To investigate the impact of cholecalciferol treatment on cardiovascular risk profiles in hypertensive patients with hypovitaminosis D.
  • To assess the effect of vitamin D (cholecalciferol and calcitriol) on miR-21 expression in vivo and in vitro.

Main Methods:

  • The HYPODD study was a double-blind, placebo-controlled trial involving hypertensive patients with low vitamin D levels.
  • Patients received either cholecalciferol or placebo. Cardiovascular risk markers and circulating miR-21 levels were measured.
  • In vitro experiments assessed calcitriol's effect on miR-21 in HEK-293 cells.

Main Results:

  • Cholecalciferol treatment significantly increased 25-hydroxyvitamin D (25OHD) levels.
  • Vitamin D supplementation reduced parathormone, total cholesterol, and LDL cholesterol in the treatment group.
  • No significant changes in circulating miR-21 levels were observed in either the cholecalciferol or placebo groups.
  • In vitro, calcitriol did not alter miR-21 expression in HEK-293 cells.

Conclusions:

  • Correction of hypovitaminosis D with cholecalciferol improves cardiovascular risk profiles in hypertensive patients.
  • Vitamin D supplementation does not appear to influence miR-21 expression in this context.

Keywords:
calcitriolcholecalciferolclinical trialhypertensionhypovitaminosis DinflammationmiR-21

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