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Relationship of Daily Coffee Intake with Vascular Function in Patients with Hypertension

Takayuki Yamaji1, Takahiro Harada1, Yu Hashimoto1

  • 1Department of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan.

Nutrients
|July 9, 2022
PubMed

Insights

Daily coffee intake may improve blood vessel function in hypertensive patients. Moderate consumption (0.5-2.5 cups) showed reduced odds of endothelial and vascular smooth muscle dysfunction.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Nutrition

Background:

  • Hypertension is a major risk factor for cardiovascular disease, often associated with impaired endothelial and vascular smooth muscle function.
  • The impact of daily coffee consumption on vascular health in hypertensive individuals remains an area of active investigation.

Purpose of the Study:

  • To investigate the association between daily coffee intake and vascular function, specifically endothelial function and vascular smooth muscle function, in patients with hypertension.
  • To determine if moderate coffee consumption is linked to improved vascular parameters in this population.

Main Methods:

  • A cross-sectional study involving 462 hypertensive patients, categorized into 'no coffee' and 'coffee' groups.
  • Vascular function assessed using flow-mediated vasodilation (endothelial function) and nitroglycerine-induced vasodilation (vascular smooth muscle function).
  • Statistical analysis included group comparisons and multivariable adjustments for confounding factors; dose-response relationship explored using cubic spline curves.

Main Results:

  • The coffee group exhibited significantly better flow-mediated vasodilation (3.3% vs 2.6%, p=0.04) and nitroglycerine-induced vasodilation (11.3% vs 9.6%, p=0.02) compared to the no coffee group.
  • After adjusting for confounders, coffee consumption was associated with significantly lower odds of endothelial dysfunction (OR: 0.55) and vascular smooth muscle dysfunction (OR: 0.50).
  • A dose-response analysis indicated that consuming 0.5 to 2.5 cups of coffee daily was associated with the lowest odds of both types of vascular dysfunction.

Conclusions:

  • Moderate daily coffee intake may exert beneficial effects on both endothelial and vascular smooth muscle function in patients with hypertension.
  • These findings suggest a potential protective role for appropriate coffee consumption in managing vascular health among hypertensive individuals.

Keywords:
coffeeendothelial functionflow-mediated vasodilationnitroglycerine-induced vasodilation

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