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Development of 3D Thermoplastic Polyurethane (TPU)/Maghemite (ϒ-Fe2O3) Using Ultra-Hard and Tough (UHT) Bio-Resin for
Ehsan Fallahiarezoudar1, Nor Hasrul Akhmal Ngadiman2, Noordin Mohd Yusof2
1Department of Industrial Engineering, Faculty of Engineering, East of Guilan, University of Guilan, Roudsar 44918, Guilan, Iran.
Polymers
|July 9, 2022
Summary
This study developed a novel 3D scaffold for soft tissue engineering using digital light processing (DLP) and a bio-resin composite. The optimized scaffold demonstrated enhanced mechanical properties and improved cell proliferation, showing promise for tissue repair applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Nanotechnology
Background:
- Soft tissue engineering scaffolds are crucial for repairing damaged tissues.
- Optimizing mechanical and biocompatibility properties is essential for scaffold success.
- Digital Light Processing (DLP) offers advanced fabrication capabilities for complex scaffold structures.
Purpose of the Study:
- To develop a novel three-dimensional (3D) scaffold for soft tissue engineering using DLP and an ultra-hard and tough (UHT) bio-resin.
- To investigate the effect of thermoplastic polyurethane (TPU) concentration and maghemite (ϒ-Fe2O3) nanoparticle content on scaffold properties.
- To evaluate the mechanical and biocompatibility characteristics of the developed scaffolds.
Main Methods:
- Fabrication of 3D scaffolds using DLP with a bio-resin composite containing TPU and ϒ-Fe2O3 nanoparticles.
- Optimization of DLP curing time to 30 seconds for perfect structure curing.
- Tensile testing to determine mechanical properties, specifically Young's Modulus.
- Biocompatibility assessment including degradation rate analysis and MTT assay for cell proliferation.
Main Results:
- The highest Young's Modulus was achieved with a scaffold composition of 15% wt/v TPU/UHT and 1% v/v ϒ-Fe2O3.
- Scaffolds incorporating ϒ-Fe2O3 nanoparticles exhibited a lower degradation rate compared to those without nanoparticles.
- MTT assay results indicated that the presence of ϒ-Fe2O3 significantly enhanced cell proliferation rates.
Conclusions:
- The developed 3D scaffold, fabricated via DLP with a TPU/UHT and ϒ-Fe2O3 composite, shows promising mechanical strength and biocompatibility.
- The incorporation of ϒ-Fe2O3 nanoparticles positively influences cell proliferation, suggesting potential for enhanced tissue regeneration.
- This novel scaffold design represents a significant advancement in soft tissue engineering applications.
