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Soluble CD36 Concentration in Diabetic Hypertensive Patients with Coronary Atherosclerosis

Amer Ali Khaleel1, Ruqaya Mohammed Ghareeb Taher Al-Barzinji2

  • 1Department Medical Microbiology, College of Health Sciences, Hawler Medical University, Erbil-Iraq. amer.khaleel@hmu.edu.krd.

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|July 9, 2022
PubMed

Insights

Soluble CD36 (sCD36) and high-sensitivity C-reactive protein (hs-CRP) show increased levels in patients with coronary atherosclerosis, particularly those with diabetes and hypertension. sCD36 is a potential diagnostic marker, correlating with BMI and lipid profiles.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Atherosclerosis Pathophysiology

Background:

  • Atherosclerosis involves cholesterol retention and arterial inflammation.
  • CD36, a membrane protein, plays a key role in oxidized LDL uptake and atherosclerosis.
  • Soluble CD36 (sCD36) and hs-CRP are potential biomarkers for cardiovascular disease.

Purpose of the Study:

  • To compare the diagnostic utility of sCD36 versus hs-CRP in patients with coronary atherosclerosis, diabetes mellitus (DM), and/or hypertension (HTN).
  • To investigate the correlation between sCD36 and hs-CRP levels in these patient groups.

Main Methods:

  • Serum sCD36 and hs-CRP levels were measured in 100 coronary atherosclerosis patients (divided into DM and/or HTN groups) and 100 controls using ELISA and immune turbidimetric assay, respectively.
  • Lipid profiles, hematological markers, and clinical data were compared across groups.

Main Results:

  • Both sCD36 and hs-CRP levels were significantly elevated in patients compared to controls (p<0.05).
  • sCD36 levels differed significantly among patient groups, with the highest levels observed in the DM-HTN group (p<0.05).
  • sCD36 showed significant positive correlations with BMI, hs-CRP, total cholesterol, and non-HDL-C (p<0.05).

Conclusions:

  • Elevated sCD36 and hs-CRP levels are associated with coronary atherosclerosis, especially in patients with diabetes and hypertension.
  • sCD36 demonstrates diagnostic potential and correlates with key metabolic and inflammatory markers in this population.

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