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Updated: Sep 5, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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Relationship between MMP-9 Gene Polymorphism and Intracranial Aneurysm

Weiwei Wang1, Zhang Guo1, Dahua Xie1

  • 1Department of Neurosurgery, Zhangzhou Hospital, Fujian Medical University, Zhangzhou, 363000, China. 598038509@qq.com.

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|July 9, 2022
PubMed

Insights

Genetic variations in matrix metalloproteinase-9 (MMP-9) are linked to intracranial aneurysms. This study found a significant correlation between MMP-9 gene polymorphism and the condition, suggesting a potential genetic predisposition.

Area of Science:

  • Genetics
  • Neuroscience
  • Biochemistry

Background:

  • Matrix metalloproteinase-9 (MMP-9) is a key enzyme regulating extracellular matrix balance.
  • MMP-9 is closely associated with the pathogenesis of intracranial aneurysms.

Purpose of the Study:

  • To investigate the relationship between MMP-9 gene polymorphism and intracranial aneurysm.
  • To determine MMP-9 concentrations and analyze gene distribution in patients with intracranial aneurysms.

Main Methods:

  • Compared MMP-9 levels and absorbance values between 98 patients (experimental group) and controls.
  • Conducted gene distribution and frequency analysis of the MMP-9 C-1562T promoter region.

Main Results:

  • The control group showed CC type (67%), CT type (31%), and TT type (2%) gene distribution.
  • The experimental group exhibited CC type (52%) and CT type (44%) gene distribution.
  • A significant correlation was found between MMP-9 gene polymorphism and intracranial aneurysm.

Conclusions:

  • MMP-9 gene polymorphism is associated with an increased risk of intracranial aneurysm.
  • Further research into MMP-9's role in aneurysm development is warranted.

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