Relationship between MMP-9 Gene Polymorphism and Intracranial Aneurysm
Weiwei Wang1, Zhang Guo1, Dahua Xie1
1Department of Neurosurgery, Zhangzhou Hospital, Fujian Medical University, Zhangzhou, 363000, China. 598038509@qq.com.
Summary
Genetic variations in matrix metalloproteinase-9 (MMP-9) are linked to intracranial aneurysms. This study found a significant correlation between MMP-9 gene polymorphism and the condition, suggesting a potential genetic predisposition.
Area of Science:
- Genetics
- Neuroscience
- Biochemistry
Background:
- Matrix metalloproteinase-9 (MMP-9) is a key enzyme regulating extracellular matrix balance.
- MMP-9 is closely associated with the pathogenesis of intracranial aneurysms.
Purpose of the Study:
- To investigate the relationship between MMP-9 gene polymorphism and intracranial aneurysm.
- To determine MMP-9 concentrations and analyze gene distribution in patients with intracranial aneurysms.
Main Methods:
- Compared MMP-9 levels and absorbance values between 98 patients (experimental group) and controls.
- Conducted gene distribution and frequency analysis of the MMP-9 C-1562T promoter region.
Main Results:
- The control group showed CC type (67%), CT type (31%), and TT type (2%) gene distribution.
- The experimental group exhibited CC type (52%) and CT type (44%) gene distribution.
- A significant correlation was found between MMP-9 gene polymorphism and intracranial aneurysm.
Conclusions:
- MMP-9 gene polymorphism is associated with an increased risk of intracranial aneurysm.
- Further research into MMP-9's role in aneurysm development is warranted.
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