Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The endoplasmic reticulum is a target organelle for trivalent dimethylarsinic acid (DMAIII)-induced cytotoxicity.

Toxicology and applied pharmacology·2012
Same author

(E)-1-{4-[Bis(4-bromo-phen-yl)meth-yl]piperazin-1-yl}-3-(4-eth-oxy-phen-yl)prop-2-en-1-one.

Acta crystallographica. Section E, Structure reports online·2012
Same author

(E)-1-{4-[Bis(4-bromo-phen-yl)meth-yl]piperazin-1-yl}-3-(4-methyl-phen-yl)prop-2-en-1-one.

Acta crystallographica. Section E, Structure reports online·2012
Same author

(E)-3-(1,3-Benzodioxol-5-yl)-1-{4-[bis-(4-meth-oxy-phen-yl)meth-yl]piperazin-1-yl}prop-2-en-1-one.

Acta crystallographica. Section E, Structure reports online·2012
Same author

Economic evaluation of first-line treatments for metastatic renal cell carcinoma: a cost-effectiveness analysis in a health resource-limited setting.

PloS one·2012
Same author

Metabolism studies of casticin in rats using HPLC-ESI-MS(n).

Biomedical chromatography : BMC·2012

Related Experiment Video

Updated: Sep 5, 2025

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform
09:24

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Published on: June 6, 2017

9.1K

Imaging moiety-directed co-assembly for biodegradation control with synchronous four-modal biotracking.

Qingsong Liu1, Ye Fu1, Bin Wu1

  • 1State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200438, China.

Biomaterials
|July 9, 2022
PubMed
Summary

We developed a novel co-assembly strategy using imaging moieties to control the biodegradation of poly(D,L-lactic acid) (PDLLA) materials. This method enables precise, real-time, four-modal in vivo imaging, correlating material degradation with mass, volume, and molecular weight changes.

Keywords:
BiodegradationBioinformation correlationBiomedical polymerDirected co-assemblyMulti-mode imaging

More Related Videos

Multimodal Optical Imaging Platform for Studying Cellular Metabolism
04:47

Multimodal Optical Imaging Platform for Studying Cellular Metabolism

Published on: June 6, 2025

615
Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
10:43

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes

Published on: July 19, 2022

2.4K

Related Experiment Videos

Last Updated: Sep 5, 2025

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform
09:24

Assembly and Tracking of Microbial Community Development within a Microwell Array Platform

Published on: June 6, 2017

9.1K
Multimodal Optical Imaging Platform for Studying Cellular Metabolism
04:47

Multimodal Optical Imaging Platform for Studying Cellular Metabolism

Published on: June 6, 2025

615
Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
10:43

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes

Published on: July 19, 2022

2.4K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Medical Imaging

Background:

  • Existing methods for controlling biomedical material biodegradation are complex, limiting multi-functionality.
  • There is a need for simple strategies to precisely control degradation rates and track parameters in real-time.

Purpose of the Study:

  • To develop a novel strategy for controlling the biodegradation rate of poly(D,L-lactic acid) (PDLLA).
  • To achieve synchronous, real-time, multi-modal in vivo imaging of material degradation.
  • To correlate imaging data with material property changes (mass, volume, molecular weight).

Main Methods:

  • Covalently introduced imaging moieties with non-covalent interaction sites into PDLLA end groups.
  • Utilized alternate non-covalent interactions (e.g., CH-π, CH-F) for polymer chain co-assembly upon compression molding.
  • Achieved synchronous four-modal imaging (X-ray computed tomography, fluorescence, photoacoustics, ultrasound) in vivo.

Main Results:

  • The co-assembly strategy effectively controlled PDLLA biodegradation, with amorphous prototypes degrading slower than higher-molecular-weight counterparts.
  • Achieved insignificant local inflammatory response.
  • Synchronous four-modal imaging provided real-time correlation of material mass, volume, and molecular weight variations in vivo, even in thick tissues.

Conclusions:

  • The imaging moiety-directed co-assembly strategy offers a simple and effective method for controlling biomedical material biodegradation.
  • This approach enables advanced theranostic systems by providing comprehensive, quantitative, and qualitative biomedical information.
  • The developed technique allows for precise monitoring of material degradation and its correlation with biological responses.