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Quality control evaluation of paediatric chocolate-based dosage forms: 3D printing vs mold-casting method
Konstantina Chachlioutaki1, Christina Karavasili1, Eleftheria-Eleni Mavrokefalou1
1Department of Pharmacy, Division of Pharmaceutical Technology, Faculty of Health Sciences, Aristotle University of Thessaloniki 54124, Greece.
International Journal of Pharmaceutics
|July 9, 2022
Summary
3D printing of personalized medications offers a superior alternative to traditional mold casting for pediatric patients. This advanced pharmaceutical compounding technique ensures accuracy and dose adjustment, meeting pharmacopoeial standards.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Personalized Medicine
Background:
- Pharmaceutical compounding prepares patient-specific dosage forms.
- Conventional methods like mold casting are frequently used in compounding.
- Ensuring pediatric-friendly and accurate dosage forms is crucial.
Purpose of the Study:
- To investigate 3D printing for pediatric-friendly personalized dosage forms.
- To compare 3D printing with mold casting for pharmaceutical compounding.
- To assess if 3D printed dosage forms meet pharmacopoeial acceptance criteria.
Main Methods:
- Preparation of chocolate-based dosage forms using 3D printing.
- Preparation of identical formulations using mold casting.
- Quality control testing including mass uniformity, content uniformity, and dose accuracy.
Main Results:
- Molded dosage forms failed critical quality control tests (mass uniformity, content uniformity, dose accuracy).
- 3D printed dosage forms successfully passed all quality control tests.
- 3D printing allowed for precise overdose adjustment in dosage forms.
Conclusions:
- 3D printing is a viable and effective method for preparing personalized pediatric dosage forms.
- 3D printing surpasses mold casting in accuracy and quality control for pharmaceutical compounding.
- This technology offers an acceptable point-of-care alternative for patient-specific medication preparation.
