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Related Concept Videos

Super-resolution Fluorescence Microscopy01:37

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Related Experiment Video

Updated: Sep 5, 2025

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
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Recent progress in upconversion nanomaterials for emerging optical biological applications.

Hao Chen1, Binbin Ding2, Ping'an Ma1

  • 1State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China.

Advanced Drug Delivery Reviews
|July 9, 2022
PubMed
Summary

Upconversion nanoparticles (UCNPs) offer promising biological optical applications, particularly in advanced imaging, detection, and therapeutic strategies like optogenetics and tumor treatments.

Keywords:
DetectionNeurotherapyOptogeneticsPhotoimmunotherapyTemperature sensingUpconversion nanoparticlesVisualization

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Area of Science:

  • Biomedical Optics
  • Nanotechnology
  • Materials Science

Background:

  • Upconversion nanoparticles (UCNPs) are emerging as versatile tools in biological applications.
  • Their unique luminescence properties enable novel imaging and therapeutic modalities.

Purpose of the Study:

  • To review the biological optical applications of UCNPs.
  • To highlight their therapeutic potential and advantages.
  • To discuss current limitations and future prospects.

Main Methods:

  • Review of recent literature on UCNP development and applications.
  • Analysis of UCNP mechanisms in luminescence, imaging, and therapy.
  • Exploration of UCNPs in optogenetics, neurotherapy, and tumor treatment.

Main Results:

  • UCNPs show significant potential in visualization, temperature sensing, and detection.
  • Applications in optogenetics, neurotherapy, and phototherapy (including photoimmunotherapy) are advancing.
  • Integration of UCNPs into therapeutic strategies is a growing area.

Conclusions:

  • UCNPs are powerful tools for biological optical applications, offering therapeutic advantages.
  • Further research is needed to overcome current limitations and fully realize their potential.
  • UCNPs are poised to play a crucial role in future biomedical innovations.