Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

Cross-reactivity

Cross-reactivity

Gastritis-II: Pathophysiology

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

Antibody Actions

Antibody Actions

Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...

Antigens Involved in Adaptive Immunity

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...

Humoral Immune Responses

Humoral Immune Responses

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pan-disease blood protein profiles of rheumatic autoimmune diseases.

Communications medicine·2026

Same author

Development and Validation of the ALARN Model: A Predictive Mortality Score for Antisynthetase Syndrome.

Arthritis & rheumatology (Hoboken, N.J.)·2026

Same author

Identification of Novel Risk Loci for Common B-Cell Lymphoma Subtypes Through Cross-Trait Analysis with Idiopathic Inflammatory Myopathies.

Cancers·2026

Same author

Elevated sST2 associates with cardiac involvement and declines after treatment in newly diagnosed patients with idiopathic inflammatory myopathies.

Arthritis research & therapy·2026

Same author

A new hope with CAR T-cell therapy for refractory idiopathic inflammatory myopathies: a systematic review.

Journal of translational medicine·2026

Same author

Etiopathogenesis of Immune-Mediated Necrotizing Myopathy: A Comprehensive Review of Recent Advances.

CNS neuroscience & therapeutics·2026

Search research articles

Related Experiment Video

Updated: Sep 5, 2025

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

Autoantibodies: Pathogenic or epiphenomenon.

Angeles S Galindo-Feria¹, Guochun Wang², Ingrid E Lundberg¹

¹Division of Rheumatology, Department of Medicine, Karolinska Institutet, Solna, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden.

Best Practice & Research. Clinical Rheumatology

|July 9, 2022

Summary

Idiopathic inflammatory myopathies (IIM) involve diverse autoimmune conditions. Myositis-specific autoantibodies (MSA) are crucial for classifying IIM, measuring disease activity, and understanding pathogenesis.

Keywords:

Autoantibodies Autoantigens Myositis Pathogenesis

More Related Videos

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

Published on: September 26, 2012

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Related Experiment Videos

Last Updated: Sep 5, 2025

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

Published on: September 26, 2012

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

Rheumatology
Immunology
Neurology

Background:

Idiopathic inflammatory myopathies (IIM) encompass heterogeneous autoimmune disorders.
Key subgroups include antisynthetase syndrome, dermatomyositis, polymyositis, immune-mediated necrotizing myopathy, and sporadic inclusion body myositis.
Autoantibodies are detected in up to 80% of IIM patients, classified as myositis-specific autoantibodies (MSA) or myositis-associated autoantibodies (MAA).

Purpose of the Study:

To provide a comprehensive overview of myositis-specific autoantibodies (MSA) in IIM.
To highlight newly identified autoantibodies targeting muscle-specific autoantigens.
To discuss the role of MSAs in clinical classification, disease activity assessment, and pathogenesis of IIM.

Main Methods:

Literature review of existing research on MSAs in IIM.
Analysis of recent findings on novel autoantibodies.
Synthesis of information regarding clinical applications and pathogenetic roles.

Main Results:

MSAs are increasingly recognized for their significance in IIM.
New autoantibodies targeting muscle-specific antigens are emerging.
MSAs have implications for classifying IIM subtypes and monitoring disease activity.

Conclusions:

Myositis-specific autoantibodies are vital biomarkers in idiopathic inflammatory myopathies.
Understanding MSAs aids in accurate diagnosis, disease management, and elucidating IIM pathogenesis.
Further research into novel MSAs may refine IIM classification and treatment strategies.