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Related Experiment Video

Updated: Sep 5, 2025

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

Do common antibiotic treatments influence emotional processing?

Katerina V-A Johnson¹, Laura Steenbergen¹

¹Leiden University, Institute of Psychology, Clinical Psychology Unit, Leiden, 2333 AK, The Netherlands.

Physiology & Behavior

|July 10, 2022

Summary

This summary is machine-generated.

Recent antibiotic use is linked to increased sadness and higher heart rate in healthy adults. This suggests potential impacts on emotional processing and the gut-brain axis, even in young individuals.

Keywords:

Antibiotics Emotional processing Heart rate Immunoglobulin A Microbiome–gut–brain axis

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Last Updated: Sep 5, 2025

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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Area of Science:

Microbiome research
Neuroscience
Psychophysiology

Background:

Antibiotics, widely prescribed, can negatively impact the human microbiome.
The gut microbiome influences physiological, neural processes, emotion, and cognition.
The microbiome-gut-brain axis involves immune and vagal signaling.

Purpose of the Study:

To investigate the association between antibiotic treatment and changes in emotional processing and mood.
To explore physiological correlates of these changes, considering the microbiome-gut-brain axis.

Main Methods:

A between-subject design was employed with 105 young healthy adult volunteers.
Psychological tests and questionnaires assessed emotional processing and mood.
Physiological measures, including heart rate, were recorded.

Main Results:

Individuals with recent antibiotic exposure (past 3 months) exhibited a stronger bias towards sadness.
A higher heart rate was observed in the antibiotic-exposed group.
Heart rate did not mediate the relationship between antibiotic use and negative emotional bias.

Conclusions:

Recent antibiotic use is associated with altered emotional processing, specifically increased sadness bias.
Findings suggest antibiotics may influence mood and emotional regulation via the gut-brain axis.
Antibiotic history may be a relevant factor for studies on emotional processing and psychophysiology.