LipoxinA4 as a Potential Prognostic Marker of COVID-19

This pilot study aimed to determine early changes of LXA₄ levels among the hospitalized patients confirmed as COVID-19 cases following the clinical management and its correlation with commonly used inflammatory markers, including erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), and ferritin. Thirty-one adult hospitalized patients infected with the non-severe COVID-19 were included. LXA₄ levels were measured at the baseline and 48-72 hours after hospitalization. Accordingly, ESR and CRP levels were collected on the first day of hospitalization. Moreover, the maximum serum ferritin levels were determined during the five days. LXA₄ levels significantly increased at 48-72 hours compared to the baseline. ESR, CRP, and ferritin levels were positively correlated with the increased LXA4. In contrast, aging was shown to negatively correlate with the increased LXA₄ levels. LXA₄ may be known as a valuable marker to assess the treatment response among non-elderly patients with non-severe COVID-19. Furthermore, LXA₄ could be considered as a potential treatment option under inflammatory conditions. Further studies are necessary to clarify LXA₄ role in COVID-19 pathogenesis, as well as the balance between such pro-resolving mediators and inflammatory parameters.