Related Experiment Video

Updated: Sep 5, 2025

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

2.0K

Emergence of the CD226 Axis in Cancer Immunotherapy

Michael Conner1, Ken W Hance1, Sapna Yadavilli1

  • 1Oncology R&D, GlaxoSmithKline, Collegeville, PA, United States.

Frontiers in Immunology
|July 11, 2022
PubMed

Insights

The CD226 axis, involving immune receptors like TIGIT, CD96, and PVRIG, is a key target in cancer immunotherapy. Understanding their interactions and therapeutic strategies is crucial for advancing treatments.

Area of Science:

  • Immunology
  • Cancer Biology
  • Pharmacology

Background:

  • Immune receptors interacting with nectin/nectin-like (necl) family members are critical in cancer.
  • CD226, TIGIT, CD96, PVRIG, and their ligands (CD155, CD112) form a complex network influencing anti-tumor immunity.
  • This network presents novel therapeutic intervention points for cancer immunotherapy.

Purpose of the Study:

  • To review the CD226 axis in cancer immunotherapy.
  • To focus on immunotherapeutic strategies targeting TIGIT, CD96, and PVRIG.
  • To explore the underlying biology, including receptor-ligand interactions and immune cell involvement.

Main Methods:

  • Literature review of the CD226 axis in cancer.
  • Analysis of current immunotherapeutic strategies targeting TIGIT, CD96, and PVRIG.
  • Integration of data on receptor-ligand interactions (cis/trans), immune populations, and Fc gamma receptor biology.

Main Results:

  • The CD226 axis represents a significant area for cancer immunotherapy development.
  • TIGIT antagonists are progressing clinically, with emerging CD96 and PVRIG-based therapies.
  • Understanding cis/trans interactions and Fc gamma receptor biology is vital for therapeutic efficacy.

Conclusions:

  • The CD226 axis offers promising avenues for cancer immunotherapy.
  • Further research into the mechanistic interplay of these receptors is needed.
  • The evolving clinical landscape highlights the therapeutic potential of targeting this axis.
Keywords:
NK cellsT cellsTreg cellsantibodiescancer immunotherapyfc gamma receptors (FcγR)

More Related Videos

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

3.5K
Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer07:55

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

1.0K

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
652
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
503
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K