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Secondary Brain Injury by Oxidative Stress After Cerebral Hemorrhage: Recent Advances

Linqian Shao1, Sichao Chen1, Li Ma1

  • 1Department of Neurosurgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Frontiers in Cellular Neuroscience
|July 11, 2022
PubMed

Intracerebral hemorrhage (ICH) is a clinical syndrome in which blood accumulates in the brain parenchyma because of a nontraumatic rupture of a blood vessel. Because of its high morbidity and mortality rate and the lack of effective therapy, the treatment of ICH has become a hot research topic. Meanwhile, Oxidative stress is one of the main causes of secondary brain injury(SBI) after ICH. Therefore, there is a need for an in-depth study of oxidative stress after ICH. This review will discuss the pathway and effects of oxidative stress after ICH and its relationship with inflammation and autophagy, as well as the current antioxidant therapy for ICH with a view to deriving better therapeutic tools or targets for ICH.

Keywords:
Nrf2cerebral hemorrhageheme oxygenaseoxidative stressresearch progress

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