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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
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Infantile ischemic stroke secondary to profound arteriopathy

Shubhi G Goli1, Ria Pal2, Sarah Lee2,3

  • 1Department of Emergency Medicine Stanford University School of Medicine Stanford University Stanford California USA.

Journal of the American College of Emergency Physicians Open
|July 11, 2022
PubMed

Insights

Pediatric arterial ischemic stroke (AIS) is rare in emergency departments. Early recognition of subtle symptoms in infants is crucial for timely diagnosis and better outcomes.

Area of Science:

  • Neurology
  • Pediatrics
  • Emergency Medicine

Background:

  • Pediatric arterial ischemic stroke (AIS) is an uncommon emergency department (ED) presentation, often challenging to diagnose.
  • Infants may present with non-specific symptoms like irritability and feeding difficulties, mimicking other conditions.

Observation:

  • A 4-month-old female presented with irritability and feeding issues, progressing to neurologic deficits including gaze and tongue deviation.
  • Imaging revealed a large right-sided cerebral infarct with diffuse extra- and intracranial vessel narrowing and tortuosity.

Findings:

  • Despite a comprehensive workup including echocardiogram and extensive laboratory testing, the etiology of the pediatric AIS remained undetermined.
  • The case underscores diagnostic challenges in pediatric AIS due to low clinical suspicion and non-specific presentations.

Implications:

  • Maintaining high clinical suspicion for pediatric AIS is vital for early diagnosis and intervention.
  • Prompt recognition and appropriate neuroimaging can lead to earlier neuroprotective measures and improved patient outcomes.

Keywords:
arteriopathybrain ischemiaimaginginfantischemic strokeneurologic emergenciespediatricpresentationrisk factors

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