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Thyroid Dysfunction and Kidney Dysfunction.
Intisar Al Fahdi1, Issa Al Salmi1,2, Fatma Al Rahbi2
1Internal Medicine, Oman Medical Specialty Board, Muscat, Oman.
Oman Medical Journal
|July 11, 2022
Summary
Thyroid dysfunction is common in chronic kidney disease (CKD) patients, with subclinical hypothyroidism being more prevalent. Early evaluation of thyroid status is crucial for managing these patients effectively.
Area of Science:
- Nephrology
- Endocrinology
- Internal Medicine
Background:
- Chronic kidney disease (CKD) incidence is rising globally, particularly in developing nations.
- Co-occurrence of autoimmune disorders, such as thyroid dysfunction, can exacerbate CKD patient conditions.
- Understanding thyroid status in CKD patients is vital for comprehensive patient care.
Purpose of the Study:
- To determine the prevalence of thyroid dysfunction in newly diagnosed chronic kidney disease patients.
- To explore the impact of thyroid dysfunction on clinical, biochemical, immunological, and hematological parameters in CKD patients.
Main Methods:
- A cross-sectional observational study was conducted.
- Data collected from newly diagnosed CKD patients without prior thyroid disease (January 2018 - December 2019).
- Thyroid status assessed at initial CKD diagnosis.
Main Results:
- Prevalence of thyroid dysfunction was 11.7% (35/290 patients).
- Subclinical hypothyroidism (62.9%) was more common than subclinical hyperthyroidism (37.1%).
- Hypothyroidism associated with higher cholesterol and LDL; hyperthyroidism with higher urea and lower hemoglobin.
Conclusions:
- Thyroid dysfunction is a frequent comorbidity in CKD patients.
- Subclinical hypothyroidism is more prevalent than subclinical hyperthyroidism in this population.
- Close clinical and laboratory monitoring is recommended due to potential subclinical hormonal axis dysfunctions.
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