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Computed Tomography

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Knowledge-based automatic plan optimization for left-sided whole breast tomotherapy.

Pier Giorgio Esposito¹, Roberta Castriconi¹, Paola Mangili¹

¹Medical Physics, San Raffaele Scientific Institute, Milano, Italy.

Physics and Imaging in Radiation Oncology

|July 11, 2022

Summary

Knowledge-Based (KB) automatic planning for tomotherapy (TT) left-sided breast irradiation yielded plans comparable or superior to manual methods. This efficient approach significantly reduces planner time and is nearing clinical implementation.

Keywords:

AI in Radiation Oncology Breast cancer Knowledge-based models Radiotherapy planning optimization Tomotherapy

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Area of Science:

Radiation Oncology
Medical Physics
Cancer Treatment

Background:

Tomotherapy offers high-quality whole breast irradiation using static angles.
Current treatment planning for left-sided breast cancer requires optimization.

Purpose of the Study:

To implement Knowledge-Based (KB) automatic planning for left-sided whole breast irradiation using tomotherapy.
To evaluate the efficacy and efficiency of KB automatic planning compared to traditional methods.

Main Methods:

A KB model was trained using 69 existing Tomotherapy (TT) clinical plans.
Virtual volumetric plans were generated and optimized using an automated template.
The KB-TT plans were validated internally (30 patients) and externally (10 patients).

Main Results:

KB-TT plans were successfully generated for most patients, with minor manual adjustments for a few.
Internal validation showed improvements in planning target volume coverage and organ-at-risk sparing compared to clinical plans.
External validation confirmed the satisfactory results, with treatment durations consistent with clinical practice and significantly reduced planner time (5-10 minutes).

Conclusions:

Knowledge-Based automatic planning for tomotherapy left-sided breast irradiation is feasible and effective.
KB-TT plans are comparable or superior to manually generated plans.
The approach offers significant time savings for radiation oncology planners and is under clinical implementation.