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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Prognosis of Ischemic Stroke Patients Undergoing Endovascular Thrombectomy is Influenced by Systemic Inflammatory
Yachen Ji1, Xiangjun Xu1, Kangfei Wu1
1Department of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, People's Republic of China.
Purpose:
The systemic immune inflammatory index (SII), as a new marker, is widely used to predict the disease prognosis. We investigated the predictive value of SII for malignant cerebral edema (MCE) and whether postoperative MCE mediates the relationship between SII and functional prognosis in patients undergoing endovascular thrombectomy (EVT).
Patients And Methods:
A total of 829 patients with anterior circulation large-vessel occlusive stroke (LVOS) were registered, and 675 (81.4%) met the inclusion criteria. We collected baseline data upon admission, including SII. Postoperative computed tomography was performed to assess the presence and grading of cerebral edema (CED), and MCE was defined as a CED score of 3. A good prognosis was defined as a modified Rankin Scale (mRS) score of 0-2 at the 90-day follow-up.
Results:
A total of 132 patients developed MCE after EVT. The patients were divided into MCE and non-MCE groups, and univariate and multifactorial analyses were performed. Among these risk factors, an elevated SII was independently correlated with the occurrence of MCE. In addition, the receiver operating characteristic (ROC) curve was used to assess the predictive capability of SII levels for prognosis. The area under the ROC was 0.69, and the optimal critical value was 2.14. In addition, postoperative MCE may partially account for the poorer functional prognosis of patients with elevated SII (regression coefficient changed by 40.3%).
Conclusion:
The SII is an independent predictor of malignant brain edema after EVT. Postoperative MCE is partly the reason for the poorer prognosis in patients with elevated SII.
Insights
The systemic immune inflammatory index (SII) predicts malignant cerebral edema after endovascular thrombectomy. Postoperative edema partially explains the poorer prognosis linked to high SII levels in stroke patients.
Area of Science:
- Neurology
- Inflammation markers
- Stroke research
Background:
- The systemic immune inflammatory index (SII) is a novel prognostic marker.
- Predicting outcomes after endovascular thrombectomy (EVT) for stroke is crucial.
- Malignant cerebral edema (MCE) is a severe complication impacting prognosis.
Purpose of the Study:
- To evaluate the predictive value of SII for MCE post-EVT.
- To determine if MCE mediates the association between SII and functional outcomes.
Main Methods:
- Retrospective analysis of 675 patients with anterior circulation large-vessel occlusive stroke (LVOS) undergoing EVT.
- Assessment of SII levels, postoperative cerebral edema (CED score), and 90-day functional prognosis (mRS).
- Statistical analyses including univariate, multifactorial, and ROC curve analysis.
Main Results:
- Elevated SII independently predicted MCE occurrence (132 patients).
- SII showed predictive capability for prognosis (AUC=0.69, critical value=2.14).
- Postoperative MCE partially mediated the effect of SII on poorer functional prognosis (40.3% mediation).
Conclusions:
- SII is an independent predictor of MCE following EVT.
- Postoperative MCE contributes to the worse functional outcomes observed in patients with elevated SII.
