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Application of AlDeSense to Stratify Ovarian Cancer Cells Based on Aldehyde Dehydrogenase 1A1 Activity
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ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism
Hanxun Yue1,2,3, Zenan Hu2,3, Rui Hu1,4
1The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Frontiers in Oncology
|July 11, 2022
Summary
Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is crucial in cancer, promoting stemness and DNA repair, but also acts as a tumor suppressor. Understanding ALDH1A1 is key for effective cancer therapy.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) is a cytoplasmic enzyme with significant physiological and pathophysiological roles.
- ALDH1A1 is implicated in various diseases, particularly in cancer development and progression.
Purpose of the Study:
- To review and summarize current research on ALDH1A1's role in cancer.
- To provide insights into ALDH1A1's mechanisms in cancer and inform therapeutic strategies.
Main Methods:
- Literature review of correlative studies on ALDH1A1 in cancer.
- Analysis of ALDH1A1's functions including cancer stem cell maintenance, metabolic modification, and DNA repair.
- Examination of epigenetic regulation of ALDH1A1 expression.
Main Results:
- ALDH1A1 can promote cancer via cancer stem cell properties, metabolic alterations, and DNA repair.
- ALDH1A1 exhibits dual roles, acting as an oncogene in some cancers and a tumor suppressor in others.
- ALDH1A1's detoxification function can lead to chemotherapy failure.
Conclusions:
- The precise mechanisms of ALDH1A1 in cancer development require further elucidation.
- ALDH1A1-targeted therapies are utilized, but a comprehensive understanding is needed for optimization.
- This review offers a current perspective on ALDH1A1 research for advancing cancer therapy.
Keywords:
aldehyde dehydrogenasescancer stem cellcarcinogenesisdrug resistancehepatocellular carcinomaMore Related Videos
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