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Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches

Talha Bin Emran1,2, Asif Shahriar3, Aar Rafi Mahmud4

  • 1Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, Bangladesh.

Frontiers in Oncology
|July 11, 2022
PubMed

Insights

Multidrug resistance (MDR) in cancer hinders effective treatment. This review explores MDR mechanisms and novel strategies like nanomedicine to overcome this challenge in cancer therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cancer remains a leading global cause of death.
  • Multidrug resistance (MDR) significantly impedes effective cancer treatment.
  • Understanding MDR is crucial for developing better therapeutic strategies.

Purpose of the Study:

  • To review known mechanisms of multidrug resistance in cancer cells.
  • To discuss current laboratory approaches and novel therapeutic strategies to combat MDR.
  • To highlight intrinsic, acquired, hypoxia-, and autophagy-mediated drug resistance.

Main Methods:

  • Literature review of existing research on cancer multidrug resistance.
  • Analysis of molecular and cellular mechanisms contributing to drug resistance.
  • Exploration of emerging therapeutic strategies and technologies.

Main Results:

  • MDR arises from genetic factors, epigenetics, drug efflux, and cell death inhibition.
  • Hypoxia and autophagy play significant roles in mediating drug resistance.
  • Expression of drug-resistant genes and regulatory mechanisms are key factors.

Conclusions:

  • Novel strategies like immunoprevention, microparticles, and nanomedicine show promise in overcoming MDR.
  • Targeting MDR mechanisms is essential for improving cancer treatment outcomes.
  • Further research into these strategies could lead to more effective cancer therapies.
Keywords:
cancerimmuno-preventionintracellular and extracellular ATPmicroRNAmultidrug resistance

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