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Tumour-associated fibroblasts (TAFs) significantly impact the tumour microenvironment (TME), influencing cancer progression and therapy resistance. Targeting TAFs offers a promising strategy to enhance anti-tumour immunity and improve cancer treatment outcomes.

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cancercancer-associated fibroblastsimmunotherapyinflammationtumour microenvironment

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Area of Science:

  • Oncology
  • Immunology
  • Cancer Biology

Background:

  • Tumours comprise heterogeneous cells, including cancer cells, immune cells, and stromal components like fibroblasts.
  • The tumour microenvironment (TME) immune status dictates tumour phenotypes, influencing malignancy or anti-malignancy responses.
  • Tumour-associated fibroblasts (TAFs) are key stromal cells in the TME, often linked to poor prognosis and therapy resistance.

Purpose of the Study:

  • To review the role of immune and stromal cells in regulating the TME's immune status.
  • To explore the therapeutic potential of targeting stromal cells, particularly TAFs, in cancer treatment.

Main Methods:

  • Literature review of recent studies on TAFs and TME immunity.
  • Analysis of TAFs' impact on tumour immunity and response to therapies.

Main Results:

  • TAFs are major TME components associated with poor prognosis and resistance to therapies, including immunotherapies.
  • Understanding TAFs' roles is crucial for modulating TME immunity and overcoming treatment resistance.

Conclusions:

  • Targeting TAFs within the TME presents a potential adjuvant therapy strategy.
  • This approach could sensitize immunosuppressive tumours, prevent cancer progression, chemo-resistance, and metastasis.