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Diagnostic Performance of Diffusion-Weighted Imaging for Colorectal Cancer Detection: An Updated Systematic Review
Yunfei Xiao1, Juan Li1, Jiamei Zhong1
1Department of Magnetic Resonance, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Background:
Magnetic resonance imaging (MRI), which uses strong magnetic fields and radio waves (radiofrequency energy) to make images, is one of the best imaging methods for soft tissues and can clearly display unique anatomical structures. Diffusion-weighted imaging (DWI) has been developed for identifying various malignant tumors.
Aim:
To investigate the diagnostic value of DWI-MRI quantitative analysis in colorectal cancer detection.
Methods:
The PubMed, Cochrane Library, and Embase databases were searched from inception to May 29, 2020. Studies published in English that used DWI-MRI for diagnosing colorectal cancer were included. Case reports, letters, reviews, and studies conducted in non-humans or in-vitro experiments were excluded. The pooled diagnostic odds ratio (DOR) and hierarchical summary receiver operating characteristic (HSROC) curves were computed for DWI, and the area under the curve (AUC) and associated standard error (SE) and 95% confidence intervals (CIs) were also used.
Results:
In total, 15 studies with 1,655 participants were finally included in this meta-analysis. There were four prospective studies and 11 retrospective studies. Eight studies focused on rectal cancer, six on colorectal cancer, and one on colonic cancer. The performance of DWI-MRI for diagnosing colorectal cancer was accurate, with pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of 0.88 (95% CI = 0.85-0.91), 0.92 (95% CI = 0.91-0.94), 30.36 (95% CI = 11.05-83.43), and 0.44 (95% CI = 0.30-0.64), respectively. The DOR and HSROC curves were 121 (95% CI = 56-261) and 0.92 (λ: 4.79), respectively.
Conclusion:
DWI showed high diagnostic accuracy for colorectal cancer detection. Further studies with large sample sizes and prospective design are needed to confirm these results.
Insights
Diffusion-weighted imaging (DWI) magnetic resonance imaging (MRI) accurately detects colorectal cancer. This meta-analysis confirms DWI-MRI
Area of Science:
- Radiology and Medical Imaging
- Oncology
- Diagnostic Techniques
Background:
- Magnetic resonance imaging (MRI) offers superior soft tissue visualization.
- Diffusion-weighted imaging (DWI) is a specialized MRI technique for detecting malignant tumors.
Conclusions:
- DWI-MRI exhibits high accuracy in detecting colorectal cancer.
- Further large-scale prospective studies are recommended to validate these findings.
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