Related Experiment Video

Updated: Sep 5, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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CDK9 inhibitors in cancer research

Zhi Huang1,2, Tianqi Wang1, Cheng Wang1

  • 1Department of Medicinal Chemistry, School of Medicine, Nankai University 94 Weijin Road Tianjin 300071 China yanfan@nankai.edu.cn.

RSC Medicinal Chemistry
|July 11, 2022
PubMed

Insights

Cyclin-dependent kinase 9 (CDK9) is crucial for gene transcription and a target in cancer therapy. This review covers CDK9 inhibitors and PROTACs for cancer research and treatment.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Drug Discovery

Background:

  • Cyclin-dependent kinase 9 (CDK9) is vital for transcriptional elongation.
  • Altered CDK9 activity is implicated in various cancers, presenting it as a therapeutic target.

Purpose of the Study:

  • To review CDK9 modulators for cancer research.
  • To discuss therapeutic applications of CDK9 inhibitors and PROTACs.

Main Methods:

  • Literature review of CDK9 modulators.
  • Analysis of small-molecule inhibitors and PROTACs targeting CDK9.

Main Results:

  • CDK9 is a validated target in oncology.
  • Development of small-molecule inhibitors and PROTACs shows promise.

Conclusions:

  • CDK9 modulators offer significant potential for cancer therapy.
  • Further research into CDK9-targeted strategies is warranted.

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